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Product Type: Composite matrix
Other related brands
Organogenesis | |
HCPCS : Q4101 (Medicare DME co-payment per billable unit min / max: $0.00 / $0.00)
Apligraf is a living, cell-based, bilayered skin substitute.
INTENDED USE: For treating chronic venous leg ulcers and diabetic foot ulcers.
CLAIMED FEATURES: The lower layer contains bovine type 1 collagen and human fibroblasts to form a dermis-like structure that produces additional matrix proteins. Human keratinocytes form an epidermal layer to replicate the structure of the human epidermis. The human keratinocytes and fibroblasts are derived from neonatal foreskins. Apligraf stimulates the patient's own cells to regenerate tissue and heal the wound through mechanisms that may include the secretion of growth factors, cytokines, and matrix proteins. Does not contain melanocytes, Langerhans' cells, macrophages, lymphocytes, or tissue structures such as blood vessels, hair follicles, and sweat glands.
Wound Reference does not produce, market, re-sell or distribute health care goods or services consumed by, or used on, patients.
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Composition: Animal-derived |
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Composition: Human dermis with/without epidermis |
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Composition: Human placenta or umbilical cord |
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Composition: Viable (living) cells |
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Configuration: Fenestrated/ meshed |
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Configuration: Flowable |
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Configuration: Sheet |
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May apply on full-thickness wounds |
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May apply over exposed tendon/ bone/ muscle |
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May apply over infected tissue |
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Processing: Cryopreserved |
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Processing: Decellularized or irradiated |
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Processing: Dehydrated |
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Processing: Fresh (limited shelf life) |
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Processing: Hydrated |
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Processing: Minimally manipulated |
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Shelf life: Greater than 2 years |
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Storage: refrigeration needed |
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Storage: room temp |
The addition of Skin Substitutes or Cellular or Tissue Based Products (CTPs) to certain wounds may afford a healing advantage over dressings and conservative treatments when these options appear insufficient to affect complete healing, after at least a 30 day period of comprehensive conservative therapy. There are currently a wide variety of bioengineered products available for soft tissue coverage to affect closure.
• Human skin allografts are derived from donated human skin (cadavers)
• Allogeneic matrices are derived from human tissue (fibroblasts or membrane)
• Composite matrices are derived from human keratinocytes, fibroblasts and xenogeneic collagen
• Acellular matrices are derived from xenogeneic collagen or tissue
For Medicare to cover this product, it needs to be ordered and applied by your clinician. A patient cannot purchase it directly from a Durable Medical Equipment (DME) store and receive reimbursement for it.
* Wound Reference does not produce, market, re-sell or distribute health care goods or services consumed by, or used on, patients.
** We do not accept paid advertising to guarantee unbiased product information
Important Notice: The product information contained on this page, including the product images and additional product materials, was collected from various supplier sources. All product claims and specifications are those of the product suppliers. Every effort has been made to ensure the accuracy of the product information, however on occasion manufacturers may alter their products or packaging without notice. Wound Reference assumes no liability for inaccuracies or misstatements about products. The properties of a product may change or be inaccurate following the posting or printing of the product information in the document, either in the print or online version. Due to product changes, information listed in this document is subject to change without notice. We recommend that you always read labels, warnings and instructions for use before using a product. Content on this site is for reference purposes and is not intended to be a substitute for professional advice given by a physician or other licensed healthcare professional.
